Tissue Factor Overexpression Involved in Many Diseases

Tissue Factor (TF) plays a critical role in intracellular signaling and the coagulation cascade, a complex set of processes related to core host defense mechanisms. When TF is over expressed, it leads to inflammation and angiogenesis (abnormal growth of blood vessels), biological processes underlying both acute and chronic diseases, including acute lung injury, sepsis, auto-immune disorders, age-related macular degeneration and cancer.

Because of TF’s critical role in the underlying pathology of many diseases, biopharmaceutical companies have historically attempted to develop therapeutic molecules that target and inhibit TF overexpression. Early efforts proved challenging because of unintended interference in the coagulation cascade, leading to clinical safety concerns related to risk of bleeding.

Iconic Therapeutics, with an in-depth understanding of TF biology and keen insight in the development of targeted monoclonal antibodies, has overcome these challenges. Our unique approach modulates the up and down regulation of multiple cytokines and chemokines without undue interference in coagulation. In doing so, we have created the potential for a whole new class of biopharmaceuticals for improved treatment of serious diseases.