William L. Greene, MD
Chief Executive Officer
Dr. Greene has been Iconic Therapeutics’ CEO and a Director since 2014, bringing 20 years as an operating executive, clinician, investor, and entrepreneur. He joined from MPM Capital, where he was Managing Director and an Investment Committee member, leading investments and serving on Boards of emerging biopharmaceutical and medical device companies.
Previously, Dr. Greene was a Senior Clinical Scientist and Epidemiologist at Genentech, responsible for clinical strategy, trial design and execution, and regulatory interactions in several therapeutic areas at all development stages, including leading the early clinical development of Lucentis®. Before that, he was a Resident in Internal Medicine and Diagnostic Radiology at Yale, and an Assistant Professor of Medicine at UCSF.
Dr. Greene received his B.A. from Wesleyan University and an M.D. from UCSF. He was a Robert Wood Johnson Clinical Scholar at Yale (clinical epidemiology) and a Howard Hughes Medical Institute Research Scholar at the NIH (neurobiology). He’s co-founder of and Senior Advisor to Pear Therapeutics and a long-standing advisor to the Bill and Melinda Gates Foundation. He’s the founding Chairman of the Board and head of the Investment Committee of the Global Health Investment Fund, the largest impact-oriented life science venture capital fund devoted to global health.
Chief Operating Officer
Mr. Smith has more than 15 years of experience leading strategy and corporate development functions for public biopharmaceutical companies. He joined Iconic from Impax Laboratories, Inc., where he served as Senior Vice President of Corporate Development and Strategy leading a wide range of functions including business development, licensing, alliance management, deal integration and portfolio management.
Previously, Mr. Smith was an Executive Director at Amgen, Inc., where he led the business case team for Amgen’s entry into biosimilars. Subsequently, he helped form the separate biosimilars business unit responsible for developing and partnering multiple active biosimilars programs. Mr. Smith also served in multiple roles of increasing responsibility at Amgen in Operations Strategy and Corporate Strategy and M&A. Prior to Amgen, Mr. Smith was a Project Leader at The Boston Consulting Group. He also was a Production Engineer and Plant Supervisor at BASF Corporation. Mr. Smith received a B.S. in chemical engineering from the University of Michigan and an M.B.A. from the McCombs School of Business at the University of Texas at Austin.
Gabriela Burian, MD, MPH
Chief Medical Officer
Dr. Burian has more than 15 years of clinical research and development experience focused on retinal disease, with extensive practice in designing, planning and executing global clinical programs. Dr. Burian joined Novartis Pharma in 2005 as Clinical Research Scientist and later held various leadership and management positions including Global Program Medical Director. She was also responsible for clinical development strategies across multiple retinal indications, including age-related macular degeneration, diabetic macular edema (DME), retinal vein occlusion (RVO) and pathologic myopia (PM). She successfully led the global (ex-U.S.) regulatory interactions and approvals of Lucentis® for DME, RVO and PM indications in more than 100 countries.
Most recently, Dr. Burian served as the Ophthalmology Early Program Leader at F. Hoffmann-La Roche, where she was responsible for establishing the translational medicine group and leading early clinical development strategy. Dr. Burian received an M.D. from Victor Babes University of Medicine and Pharmacy in Romania, and a Master’s in Public Health in epidemiology from Rollins School of Public Health at Emory University. After completing her graduate work, Dr. Burian was a Clinical Research Manager and member of the faculty in the Ophthalmology Department at Emory University.
Head of Development Operations
Cynthia has over 30 years of clinical operations, project and portfolio management. Her experience encompasses ophthalmology, oncology, and immunology among other indications. Cynthia has various leadership positions at Roche, Genentech and AbbVie. Cynthia led the Lucentis clinical operations team through Phase 3. She has a B.S.N. from the University of Northern Colorado and an M.B.A from City University.